Detall de la convocatòria

Característiques

Característica
Objectiu de la convocatòria
The Alzheimer's Drug Discovery Foundation (ADDF) funds drug discovery and development research programs in the field of Alzheimer's disease (AD), related dementias and cognitive aging. The ADDF seeks to fill the critical translational funding gap between basic research and later stage drug development by funding promising drug discovery and development programs. In addition to funding academic programs, the ADDF also invests in and creates early stage biotechnology companies. The ADDF also co-sponsors conferences to stimulate new ideas and approaches in areas of interest to the Foundation.
Característiques principals
Research investigating the pathogenic mechanisms underlying frontotemporal degeneration (FTD) is advancing, creating new targets for drug discovery. However, there remains a global gap in FTD drug discovery research. The Alzheimer's Drug Discovery Foundation (ADDF) and The Association for Frontotemporal Degeneration (AFTD) seek to accelerate and support innovative small molecule and biologic (antibodies, oligonucleotides, peptides, gene therapy) drug discovery programs for FTD through this request for proposals (RFP).

Priority areas for this program include:
  • Lead optimization of novel disease-modifying compounds, including medicinal chemistry refinement and in vitro ADME.
  • In vivo testing of novel lead compounds, biologics, or repurposed drug candidates in relevant animal models for pharmacokinetics, dose-range finding, target engagement, in vivo efficacy, and/or preliminary rodent tolerability studies.
    • Lloc de presentació
    El personal de l'IMIM i PSMAR que necessiteu més informació adreceu-vos a:
    Servei de Recerca. C/ Doctor Aiguader, 88. 08003-Barcelona. Tel.: 93.316.05.76.
    Marta López: mlopez4@imim.es Ext.: 1576
    Carol Barnwell: cbarnwell@imim.es Ext.: 1670
    Convocatòria (URL)
    https://www.alzdiscovery.org/research-and-grants/funding-opportunities/accelerating-drug-discovery-for-ftd
    Applications:
    https://addf.fluxx.io/
    Dotació
    Budgets averaging $100,000-$150,000 are recommended.
    Durada
    1 year with potential for follow-on funding.
    AVÍS IMPORTANT
    The deadline for applications is August 10, 2019. Submission of a Letter of Intent (LOI) is required on or before July 12, 2019. LOIs are reviewed on a rolling basis and can be submitted any time prior to the deadline.

    Arxius

    Arxiu
    Funding Opportunities_ Application & Funding Policies _ Alzheimer's Drug Discovery Foundation.pdf
    Application Instructions for Core RFPs _ Alzheimer's Drug Discovery Foundation.pdf
    Request for Proposals_ Accelerating Drug Discovery for Frontotemporal Degeneration _ Alzheimer's Drug Discovery Foundation.pdf